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553031

Sigma-Aldrich

RAGE Antagonist Peptide, RAP

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

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Synonym(s):
RAGE Antagonist Peptide, RAP, ELKVLMEKEL
Empirical Formula (Hill Notation):
C57H101N13O17S
Molecular Weight:
1272.55

Quality Level

assay

≥95% (HPLC)

form

powder

potency

2 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 5 mg/mL

shipped in

dry ice

storage temp.

−20°C

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assay

≥95% (HPLC)

assay

≥97% (elemental analysis)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 5 mg/mL

solubility

water: 30 mg/mL

solubility

water: 25 mg/mL

solubility

water: 4 mg/mL, DMSO: 50 mg/mL

General description

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

Biochem/physiol Actions

Primary Target
RAGE
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-ELKVLMEKEL-NH2

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Helena Choltus et al.
International journal of molecular sciences, 22(15) (2021-08-08)
Maternal smoking is a risk factor of preterm prelabor rupture of the fetal membranes (pPROM), which is responsible for 30% of preterm births worldwide. Cigarettes induce oxidative stress and inflammation, mechanisms both implicated in fetal membranes (FM) weakening. We hypothesized

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