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557303

Sigma-Aldrich

Rifampicin

Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

Synonym(s):
Rifampicin, Rifampin, 3-(4-Methylpiperazinyliminomethyl)rifamycin SV
Empirical Formula (Hill Notation):
C43H58N4O12
CAS Number:
Molecular Weight:
822.94
MDL number:

Quality Level

Assay

~97-102% (by Assay)

form

powder (or crystals)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

brown-red to brick red

solubility

acetone and ethanol: slightly soluble
water and methanol: slightly soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

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This Item
R07000001604009PHR1806
Rifampicin Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

Sigma-Aldrich

557303

Rifampicin

Rifampicin European Pharmacopoeia (EP) Reference Standard

R0700000

Rifampicin

Rifampin United States Pharmacopeia (USP) Reference Standard

USP

1604009

Rifampin

Rifampin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1806

Rifampin

assay

~97-102% (by Assay)

assay

-

assay

-

assay

-

form

powder (or crystals)

form

-

form

-

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

color

brown-red to brick red

color

-

color

-

color

-

solubility

acetone and ethanol: slightly soluble, water and methanol: slightly soluble

solubility

-

solubility

-

solubility

-

General description

Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.
Antibiotic that specifically inhibits DNA-dependent bacterial RNA polymerase by forming an inactive complex with RNA polymerase. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Biochem/physiol Actions

Primary Target
DNA-dependent RNA polymerase in bacteria

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Jin, D.J. and Turnbough, Jr., C.L. 1994. J. Mol. Biol. 236, 72.
Levin, M.E. and Hatfull, G.F. 1993. Mol. Microbiol. 8, 277.
Wehrli, W., et al. 1968. Proc. Natl. Acad. Sci. USA61, 667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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