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565749

Sigma-Aldrich

β-Secretase Inhibitor II

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

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Synonym(s):
β-Secretase Inhibitor II, Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
Empirical Formula (Hill Notation):
C25H39N3O5
CAS Number:
263563-09-3
Molecular Weight:
461.59

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

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565788565755565780
β-Secretase Inhibitor II The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565749

β-Secretase Inhibitor II

β-Secretase Inhibitor IV β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC₅₀ = 15 nM for human BACE-1).

Sigma-Aldrich

565788

β-Secretase Inhibitor IV

γ-Secretase Inhibitor II The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565755

γ-Secretase Inhibitor II

Sigma-Aldrich

Sigma-Aldrich

565780

β-Secretase Inhibitor III

form

solid

form

solid

form

solid

form

lyophilized

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

color

white

color

white

color

-

solubility

DMSO: 5 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 10 mM

solubility

DMSO: 1 mg/mL

General description

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
β-secretase
Product does not compete with ATP.
Reversible: yes
Target IC50: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Leu-Leu-CHO

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Sarah Bui et al.
Methods in molecular biology (Clifton, N.J.), 2557, 453-493 (2022-12-14)
In this chapter, we provide a detailed guide for the application of commonly used small molecules to study Golgi structure and function in vitro. Furthermore, we have curated a concise, validated list of endomembrane markers typically used in downstream assays

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