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565840

Sigma-Aldrich

SHIP2 Inhibitor, AS1938909

The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonym(s):
SHIP2 Inhibitor, AS1938909, 3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) Inhibitor, AS1938909
Empirical Formula (Hill Notation):
C19H13Cl2F2NO2S
Molecular Weight:
428.28

Quality Level

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

2-8°C

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341310565835361553
SHIP2 Inhibitor, AS1938909 The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

565840

SHIP2 Inhibitor, AS1938909

FABP4 Inhibitor The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

341310

FABP4 Inhibitor

Sigma-Aldrich

565835

SHIP1 Inhibitor, 3AC

GSK-3β Inhibitor XI The GSK-3β Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

361553

GSK-3β Inhibitor XI

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (1H-NMR)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

ethanol: 20 mg/mL, DMSO: 50 mg/mL, methanol: 50 mg/mL

solubility

ethanol: 100 mg/mL, DMSO: insoluble

solubility

DMSO: 5 mg/mL

General description

A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki = 0.44 µM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50 = 0.18, 0.57, 21, >50, >50 and >50 µM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available (Cat. No. 565835).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Suwa, A., et al. 2010. Eur. J. Pharmacol.642, 177.
Suwa, A., et al. 2009. Br. J. Pharmacol.158, 879.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Petr Fojtík et al.
Frontiers in cell and developmental biology, 8, 607444-607444 (2021-02-09)
Mild hypoxia (5% O2) as well as FGFR1-induced activation of phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and MAPK signaling pathways markedly support pluripotency in human pluripotent stem cells (hPSCs). This study demonstrates that the pluripotency-promoting PI3K/AKT signaling pathway is surprisingly attenuated

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