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Key Documents

567021

Sigma-Aldrich

Simvastatin, Sodium Salt - Calbiochem

Synonym(s):

L-Type Calcium Channel Blocker VI, Simvastatin, Sodium Salt - Calbiochem

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About This Item

Linear Formula:
C25H39O6.Na
UNSPSC Code:
51111800
NACRES:
NA.32
This product is sold exclusively by Millipore via offline channels. Contact Customer Service

form

(Beige solid)

Quality Level

storage condition

OK to freeze

solubility

soluble (DMSO (100 mg/ml), Ethanol (25 mg/ml), or H2O (5 mg/ml))

storage temp.

−20°C

Related Categories

General description

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.

Certificates of Analysis (COA)

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