579002

Sigma-Aldrich

Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem

A cell-permeable, active metabolite of Tamoxifen that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Synonym(s):
(Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II, Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem
Empirical Formula (Hill Notation):
C26H29NO2
CAS Number:
Molecular Weight:
387.51
MDL number:
NACRES:
NA.77

storage conditions

+2C to +8C

Quality Level

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

methanol: 10 mg/mL
ethanol: 20 mg/mL (heating may be required)

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

DODQJNMQWMSYGS-QPLCGJKRSA-N

General description

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).
A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
PKC

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

hazcat

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Dawn Savery et al.
Birth defects research, 112(2), 196-204 (2019-12-04)
CreERT2-mediated gene recombination is widely applied in developmental biology research. Activation of CreERT2 is typically achieved by injection of tamoxifen in an oily vehicle into the peritoneal cavity of mid-gestation pregnant mice. This can be technically challenging and adversely impacts...

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