MilliporeSigma
All Photos(1)

Documents

580555

Sigma-Aldrich

Paclitaxel, Taxus sp.

Antitumor and antileukemic agent isolated from the bark of the yew tree.

Sign Into View Organizational & Contract Pricing

Synonym(s):
Paclitaxel, Taxus sp., Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
Empirical Formula (Hill Notation):
C47H51NO14
CAS Number:
Molecular Weight:
853.91
MDL number:

Quality Level

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

methanol: 1 mg/mL
DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1

InChI key

RCINICONZNJXQF-VAZQATRQSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
T1912T7402PHR1803
Paclitaxel, Taxus sp. Antitumor and antileukemic agent isolated from the bark of the yew tree.

580555

Paclitaxel, Taxus sp.

Paclitaxel from Taxus yannanensis, powder

T1912

Paclitaxel

Paclitaxel from Taxus brevifolia, ≥95% (HPLC), powder

T7402

Paclitaxel

Paclitaxel Pharmaceutical Secondary Standard; Certified Reference Material

PHR1803

Paclitaxel

assay

≥97% (HPLC)

assay

-

assay

≥95% (HPLC)

assay

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

300

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated

storage condition

-

storage condition

-

storage condition

-

General description

Antitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
Antitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Promotes assembly of microtubules and inhibits tubulins disassembly
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol.35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci.97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Taxol is a registered trademark of Bristol-Myers Squibb Co.

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Muta. 2 - Repr. 1B - STOT RE 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 8

1 of 8

Paclitaxel European Pharmacopoeia (EP) Reference Standard

Y0000698

Paclitaxel

Paclitaxel United States Pharmacopeia (USP) Reference Standard

USP

1491332

Paclitaxel

Baccatin III ≥95% (HPLC)

Sigma-Aldrich

B8154

Baccatin III

Cisplatin Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Sigma-Aldrich

232120

Cisplatin

Latrunculin A from sea sponge, ≥85% (HPLC), waxy solid

Sigma-Aldrich

L5163

Latrunculin A

FTY720 ≥98% (HPLC)

Sigma-Aldrich

SML0700

FTY720

Related Content

Exploring genotoxicity and DNA damage through multiplexing with MILLIPLEX® multiplex genotoxicity assays using Luminex® xMAP® technology enables the high-throughput measurement of phosphorylation levels of multiple proteins simultaneously and reduces sample volume, time, and cost.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service