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Key Documents

605157

Sigma-Aldrich

Thrombin, Bovine

Synonym(s):

Thrombin, Bovine

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About This Item

CAS Number:
9002-04-4
MDL number:
MFCD08457579
UNSPSC Code:
12352204
NACRES:
NA.25
Pricing and availability is not currently available.

description

Merck USA index - 14, 9383

Quality Level

100

form

lyophilized

specific activity

≥1800 NIH units/mg protein
≥50 NIH units/mg dry wt

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

0.05 M NaCl: ≤2000 NIH units/mL
water: >2000 NIH units/mL

shipped in

ambient

storage temp.

−20°C

General description

Native, bovine thrombin. Key enzyme in the coagulation cascade. Converts fibrinogen into fibrin and activates factor XIII, which cross-links and stabilizes the fibrin polymer. Has a pH of 6.0-7.5 in a 7% solution.
Native, bovine thrombin. Key enzyme that activates factor XIII and converts fibronogen into fibrin.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Harmful (C)

Unit Definition

One unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.

Physical form

Lyophilized from 50 mM Sodium Citrate, 0.2 M NaCl, 0.1% PEG-8000, pH 6.5.

Reconstitution

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 months at -70°C.





From Catalog:

Desc. Field- added "Key enzyme that activates factor XIII and converts fibronogen into fibrin."

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Weijia Luo et al.
Communications biology, 3(1), 114-114 (2020-03-12)
Exosomes are secreted extracellular vesicles with lipid bilayer membranes. They are emerging as a new category of messengers that facilitate cross-talk between cells, tissues, and organs. Thus, a critical demand arises for the development of a sensitive and non-invasive tracking

Questions

1–2 of 2 Questions  

  1. If I reconstitute the thrombin with 10 ml of water, hoe many units of thrombin will be present per ml?

    1 answer

    1. Dissolving 1,000 units of thrombin in 10 ml of water results in a concentration of 100 units per ml.

      Helpful?

  2. What volume of water do I reconstitute this powder with for the 1 kU bottle?

    1 answer

    1. 1KU can be reconstituted with 200 ul of deionized water just prior to application.

      Helpful?

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