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613560

Sigma-Aldrich

TMPyP4

≥90% (TLC), solid, telomerase inhibitor, Calbiochem®

Synonym(s):

TMPyP4, meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate

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$134.00

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25 MG
$134.00

About This Item

Empirical Formula (Hill Notation):
C44H38N8 · C28H28O12S4
CAS Number:
Molecular Weight:
1363.60
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

Quality Level

assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

purple

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3

InChI key

AKZFRMNXBLFDNN-UHFFFAOYSA-K

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This Item
581011444252475872
TMPyP4 A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

613560

TMPyP4

MnTMPyP Cell-permeable superoxide dismutase (SOD) mimetic.

475872

MnTMPyP

form

solid

form

solid

form

solid

form

solid

assay

≥90% (TLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (TLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 1 mg/mL

solubility

DMSO: 5 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 100 mg/mL

solubility

water: 1 mg/mL

General description

A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 6.5 µM inhibiting human telomerase

Warning

Toxicity: Standard Handling (A)

Other Notes

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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