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614310

TLR3/dsRNA Complex Inhibitor

≥99% (HPLC), solid, TLR3/dsRNA complex inhibitor, Calbiochem®

Synonym(s):

TLR3/dsRNA Complex Inhibitor, ( R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

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10 MG

$222.00

$222.00

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About This Item

Empirical Formula (Hill Notation):
C18H13ClFNO3S
Molecular Weight:
377.82
UNSPSC Code:
12352200
NACRES:
NA.28
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

Key Documents

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Product Name

TLR3/dsRNA Complex Inhibitor, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.

Quality Level

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

2-8°C

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614316401481361550
TLR3/dsRNA Complex Inhibitor The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.

Sigma-Aldrich

614310

TLR3/dsRNA Complex Inhibitor

TLR4 Inhibitor, TAK-242 TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

Sigma-Aldrich

614316

TLR4 Inhibitor, TAK-242

IKK-2 Inhibitor IV The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

401481

IKK-2 Inhibitor IV

GSK-3 Inhibitor IX BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells.

Sigma-Aldrich

361550

GSK-3 Inhibitor IX

form

solid

form

solid

form

solid

form

solid

assay

≥99% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

Disclaimer

Toxicity: Standard Handling (A)

General description

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >>100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).

Other Notes

Cheng, K., et al. 2011. J. Am. Chem. Soc.133, 3764.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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