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616400-M

Millipore

Tranilast

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

Synonym(s):
Tranilast, N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
Empirical Formula (Hill Notation):
C18H17NO5
CAS Number:
Molecular Weight:
327.33
MDL number:

Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 200 mg/mL

storage temp.

−20°C

InChI

1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

InChI key

NZHGWWWHIYHZNX-CSKARUKUSA-N

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This Item
T031816730011672687
Tranilast An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

Millipore

616400-M

Tranilast

Tranilast ≥98% (HPLC), powder

Sigma-Aldrich

T0318

Tranilast

USP

USP

1673001

Travoprost

Trandolapril United States Pharmacopeia (USP) Reference Standard

USP

1672687

Trandolapril

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

solid

form

powder

form

-

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

USP

manufacturer/tradename

USP

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

-

storage condition

-

color

pale yellow

color

white to beige

color

-

color

-

solubility

DMSO: 200 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

-

solubility

-

General description

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.

Biochem/physiol Actions

Primary Target
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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