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625625

Millipore

Trehalose, Dihydrate

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

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Synonym(s):
Trehalose, Dihydrate, 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
MDL number:

Quality Level

Assay

≥97.5% (by Assay)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 100 mg/mL

cation traces

Fe: <5 ppm
heavy metals: <10 ppm

shipped in

ambient

storage temp.

15-25°C

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

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This Item
90210T0167T5251
Trehalose, Dihydrate Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

Millipore

625625

Trehalose, Dihydrate

D-(+)-Trehalose dihydrate suitable for microbiology, &#8805;99.0%, composed of two &#945;-glucose units that is used as a protectant, stabilizer and to support proper folding

Millipore

90210

D-(+)-Trehalose dihydrate

form

solid

form

powder

form

powder

form

powder

solubility

water: 100 mg/mL

solubility

H2O: 0.1 g/mL, clear, colorless

solubility

H2O: 50 mg/mL

solubility

-

cation traces

Fe: <5 ppm, heavy metals: <10 ppm

cation traces

As: ≤0.1 mg/kg, Ca: ≤200 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤10 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤10 mg/kg

cation traces

-

cation traces

-

storage temp.

15-25°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

300

General description

Non-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.
Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.

Warning

Toxicity: Standard Handling (A)

Other Notes

Sarkar, S., et al. 2007. J. Biol. Chem. In press.
Tanaka, M., et al. 2004. Nat. Med.10, 148.
Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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