625625 is a research use reagent that is not provided sterile. It will be up to the user to determine its suitability for in vivo use.
625625
Trehalose, Dihydrate
Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.
Synonym(s):
Trehalose, Dihydrate, 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
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| Size/SKU | Availability | Price |
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50 g | Check Cart for Availability | $123.00 |
1 kg | Check Cart for Availability | $1,570.00 |
About This Item
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
UNSPSC Code:
12352201
NACRES:
NA.79
MDL number:
description
Merck USA index - 14, 9580
Quality Segment
assay
≥97.5% (by Assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: 100 mg/mL
cation traces
Fe: <5 ppm, heavy metals: <10 ppm
shipped in
ambient
storage temp.
15-25°C
SMILES string
O1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO.O.O
InChI
1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
InChI key
DPVHGFAJLZWDOC-PVXXTIHASA-N
General description
Non-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.
Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.
Other Notes
Sarkar, S., et al. 2007. J. Biol. Chem. In press.
Tanaka, M., et al. 2004. Nat. Med.10, 148.
Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.
Tanaka, M., et al. 2004. Nat. Med.10, 148.
Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
1 of 1
This Item | |||
|---|---|---|---|
| description Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. | description ≥99.0%, suitable for microbiology, composed of two α-glucose units that is used as a protectant, stabilizer and to support proper folding | description from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99% | description ≥99% (HPLC), from starch |
| assay ≥97.5% (by Assay) | assay ≥99.0% (HPLC) | assay ≥99% | assay ≥99% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| solubility water: 100 mg/mL | solubility H2O: 0.1 g/mL, clear, colorless | solubility H2O: 50 mg/mL | solubility water: 50 mg/mL, clear, colorless to very faintly yellow |
| form solid | form powder | form powder | form powder |
| storage temp. 15-25°C | storage temp. - | storage temp. - | storage temp. room temp |
| cation traces Fe: <5 ppm, heavy metals: <10 ppm | cation traces As: ≤0.1 mg/kg, Ca: ≤200 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤10 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤10 mg/kg | cation traces - | cation traces - |
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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