All Photos(1)

647950-M

Millipore

Triclosan - CAS 3380-34-5 - Calbiochem

A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase.

Synonym(s):
5-Chloro-2-(2,4-dichlorophenoxy)phenol, Triclosan - CAS 3380-34-5 - Calbiochem
Empirical Formula (Hill Notation):
C12H7Cl3O2
CAS Number:
Molecular Weight:
289.54
MDL number:

Quality Level

assay

≥97% (HPLC)

form

crystalline powder
powder

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL
ethanol: 50 mg/mL

storage temp.

−20°C

InChI

1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H

InChI key

XEFQLINVKFYRCS-UHFFFAOYSA-N

General description

A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase. A slow-binding inhibitor that forms a stable ternary complex (bsFabl.NAD+.triclosan) in Bacillus subtilis.
A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fab l encoded enoyl-acyl carrier protein (ACP) reductase. A slow binding inhibitor that forms a stable ternary complex (bsFabl.NAD+. triclosan) in Bacillus subtilis. Also inhibits the growth of Plasmodium falciparum by inhibiting the apicomplexan Fab I (IC50 = 154.4 ng/ml for W2 strain and 387 ng/ml for D6 strain).

Warning

Toxicity: Environmental Hazard (N)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

McLeod, R., et al. 2001. Int. J. Parasitology31, 109.
Surolia, N. and Surolia, A., 2001. Nat. Medicine7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem.275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem.274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol.181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature394, 531.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service