658395

Sigma-Aldrich

AG 18 - CAS 118409-57-7 - Calbiochem

A broad-spectrum protein tyrosine kinase inhibitor.

Synonym(s):
α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810, AG 18 - CAS 118409-57-7 - Calbiochem
Empirical Formula (Hill Notation):
C10H6N2O2
CAS Number:
Molecular Weight:
186.17
MDL number:

storage conditions

-20C

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 100 mg/mL
ethanol: 50 mg/mL
acetic acid: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChI key

VTJXFTPMFYAJJU-UHFFFAOYSA-N

General description

A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
A cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Primary Target
epidermal growth factor receptor autophosphorylation
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC50: 40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Jaleel, M., et al. 2004. Biochemistry43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem.270, 28325.
Williams, J.A. 1994. Am. J. Physiol.267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem.265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol.40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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