658548

Sigma-Aldrich

InSolution AG 1478 - CAS 175178-82-2 - Calbiochem

Synonym(s):
InSolution AG 1478 - CAS 175178-82-2 - Calbiochem
Empirical Formula (Hill Notation):
C16H14ClN3O2
CAS Number:
Molecular Weight:
315.75
MDL number:

storage conditions

-20C

Quality Level

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

clearfaint tan

shipped in

wet ice

storage temp.

−20°C

General description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 >100 µM), the platelet-derived growth factor (PDGF) receptor (IC50 >100 µM), and p210Bcr-Abl (IC50 >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Packaging

1 mg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Primary Target
Epidermal growth factor receptor kinase
Reversible: yes
Cell permeable: yes
Product competes with ATP.
Target IC50: 3 nM against of epidermal growth factor receptor kinase

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Levitski, A., and Gazit, A. 1995. Science267, 1782.
Fry, D.W., et al. 1994. Science265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

Legal Information

Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 2

Flash Point(F)

188.6 °F - (Dimethylsulfoxide)

Flash Point(C)

87 °C - (Dimethylsulfoxide)

Certificate of Analysis

Certificate of Origin

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