InSolution AG 1478 - CAS 175178-82-2 - Calbiochem

InSolution AG 1478 - CAS 175178-82-2 - Calbiochem
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:

storage conditions


Quality Level


≥98% (HPLC)





storage condition

OK to freeze
protect from light


clearfaint tan

shipped in

wet ice

storage temp.


General description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 >100 µM), the platelet-derived growth factor (PDGF) receptor (IC50 >100 µM), and p210Bcr-Abl (IC50 >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.


1 mg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Primary Target
Epidermal growth factor receptor kinase
Reversible: yes
Cell permeable: yes
Product competes with ATP.
Target IC50: 3 nM against of epidermal growth factor receptor kinase


Toxicity: Irritant (B)

Physical form

A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.


Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Levitski, A., and Gazit, A. 1995. Science267, 1782.
Fry, D.W., et al. 1994. Science265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

Legal Information

Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany


Flash Point(F)

188.6 °F - (Dimethylsulfoxide)

Flash Point(C)

87 °C - (Dimethylsulfoxide)

Certificate of Analysis

Certificate of Origin

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.