662056

Ubiquitin Aldehyde

≥95% (HPLC), liquid, ubiquitin hydrolase inhibitor, Calbiochem^®

• Synonym(s): ubiquitin hydrolase inhibitor
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Ubiquitin Aldehyde, Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover.
• Quality Level: 100
• assay: ≥95% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: DMSO: 50 mg/mL; aqueous buffer: soluble
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease the rates of ubiquitin-dependent degradation.

Biochem/physiol Actions

Cell permeable: no

Primary Target
multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover

Product does not compete with ATP.

Reversible: no

Shown to inhibit the activity of Isopeptidase T (Cat. No. 419700) and Ubiquitin C-Terminal Hydrolase (Cat. No. 662090)

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 150 mM HCL.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Melandri, F., et al. 1996. Biochemistry 35, 12893.
Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable