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662088

Sigma-Aldrich

UCH-L1 Inhibitor II

The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

UCH-L1 Inhibitor II, Ubiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946

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About This Item

CAS Number:
UNSPSC Code:
12352200

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

brown

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

General description

A thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Mermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett.17, 3729.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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