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681673

Wnt Antagonist III, Box5

The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Wnt Antagonist III, Box5, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist

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10 MG

$270.00

$270.00

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About This Item

Empirical Formula (Hill Notation):
C30H50N6O13S2
Molecular Weight:
766.88
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

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Product Name

Wnt Antagonist III, Box5, The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

assay

≥90% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 4 mg/mL
DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

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654255475846681669
Wnt Antagonist III, Box5 The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681673

Wnt Antagonist III, Box5

TNF-α Antagonist The TNF-α Antagonist controls the biological activity of TNF-α.

Sigma-Aldrich

654255

TNF-α Antagonist

MIF Antagonist III, 4-IPP

Sigma-Aldrich

475846

MIF Antagonist III, 4-IPP

Wnt Antagonist I, IWR-1-endo Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC50 = 131 nM) & TNKS2/PARP5b (IC50 = 56 nM). Suppress Wnt-stimulated transcription activity (IC50 = 180 nM).

Sigma-Aldrich

681669

Wnt Antagonist I, IWR-1-endo

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

form

lyophilized solid

form

lyophilized

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

water: 4 mg/mL, DMSO: 50 mg/mL

solubility

water: 1 mg/mL, 5% acetic acid: 5 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL

Disclaimer

Toxicity: Standard Handling (A)

General description

A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.

Other Notes

Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem.281, 2740.
t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Krishan G Jain et al.
American journal of physiology. Lung cellular and molecular physiology, 323(5), L515-L524 (2022-09-14)
Failure to regenerate injured alveoli functionally and promptly causes a high incidence of fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-1 (PAI-1) regulates the lineage of alveolar type 2 (AT2) cells for re-alveolarization has not been studied.
Chao Liu et al.
Science advances, 9(4), eadd8977-eadd8977 (2023-01-28)
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge of the transcriptional programs underlying each stage of CESC is lacking, and important questions remain. We performed single-cell RNA
Yiming Fang et al.
NPJ precision oncology, 8(1), 7-7 (2024-01-09)
Frequent relapse and chemoresistance cause poor outcome in ovarian cancer (OC) and cancer stem cells (CSCs) are important contributors. While most studies focus exclusively on CSCs, the role of the microenvironment in providing optimal conditions to maintain their tumor-initiating potential
Sally Yunsun Kim et al.
Frontiers in cell and developmental biology, 12, 1349312-1349312 (2024-03-13)
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant Wnt signalling is associated with lung diseases including emphysema, idiopathic

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