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8.01663

Sigma-Aldrich

Boron trifluoride-methanol complex

(20% solution in methanol) for synthesis

Synonym(s):

BF3 methanol

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$25.20
100 ML
$38.30
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$111.00

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10 ML
$25.20
100 ML
$38.30
500 ML
$111.00

About This Item

UNSPSC Code:
12352301
NACRES:
NA.22
grade:
synthesis grade
vapor pressure:
4 hPa ( 20 °C)

$25.20


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grade

synthesis grade

Quality Level

vapor pressure

4 hPa ( 20 °C)

form

liquid

autoignition temp.

420 °C

expl. lim.

5.5 % (v/v) Methanol()

dilution

(for synthesis)

transition temp

flash point 16 °C

density

0.89 g/cm3 at 20 °C

storage temp.

2-30°C

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This Item
61626B1252434280
Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

form

liquid

form

-

form

liquid

form

liquid

expl. lim.

5.5 % (v/v) Methanol)

expl. lim.

-

expl. lim.

-

expl. lim.

-

density

0.89 g/cm3 at 20 °C

density

0.859 g/mL at 25 °C

density

0.859 g/mL at 25 °C

density

1.268 g/mL at 25 °C (lit.)

autoignition temp.

420 °C

autoignition temp.

-

autoignition temp.

-

autoignition temp.

-

vapor pressure

4 hPa ( 20 °C)

vapor pressure

-

vapor pressure

-

vapor pressure

-

General description

Boron trifluoride-methanol complex (BF-M) is Lewis acid boron trifluoride incoordination with methanol. BF-M is a powerful acidic catalyst for the esterification of fatty acids. In the deacetylation of acetanilides, the complex displayed excellent deprotection selectivity against amino-protecting groups.[1][2]

Application

Boron trifluoride-methanol complex is used:
  • As a reagent for deprotection of N-acetyl derivatives (acetylated amines of cyanine-type dyes).[3]
  • As a starting material in the automated radiosynthesis procedure for [18F]tetrafluoroborate.[4]

Analysis Note

Assay BF3 (acidimetric): 14.0 - 16.0 %
Density (d 20 °C/ 4 °C): 0.880 - 0.895

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

60.8 °F

flash_point_c

16 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Boron trifluoride--methanol complex-mild and powerful reagent for deprotection of labile acetylated amines
Miltsov S, et al.
Tetrahedron Letters, 44(11), 2301-2303 (2003)
Comparison of transesterification methods for production of biodiesel from vegetable oils and fats
Demirbas A
Energy Conversion and Management , 49(1), 125-130 (2008)
High molar activity [18F] tetrafluoroborate synthesis for sodium iodide symporter imaging by PET
Soloviev D, et al.
EJNMMI radiopharmacy and chemistry, 7(1), 1-17 (2022)
Boron trifluoride--methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity
Miltsov S, et al.
Tetrahedron Letters, 57(6), 641-644 (2016)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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