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8.51008

Sigma-Aldrich

TBTU

2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®

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Synonym(s):
TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate
Empirical Formula (Hill Notation):
C11H16BF4N5O
CAS Number:
Molecular Weight:
321.08
MDL number:
EC Index Number:
423-040-4

Quality Level

product line

Novabiochem®

Assay

≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Coupling Reactions

manufacturer/tradename

Novabiochem®

mp

195-199 °C (decomposes)

application(s)

peptide synthesis

storage temp.

15-25°C

InChI

1S/C11H16N5O.B.4FH/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;;;;;/h5-8H,1-4H3;;4*1H/q+1;+3;;;;/p-4

InChI key

SHGLJDNRZIDILW-UHFFFAOYSA-J

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This Item
8.510128.510068.51088
TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®

Sigma-Aldrich

8.51008

TBTU

HCTU O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®

Sigma-Aldrich

8.51012

HCTU

HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®

Sigma-Aldrich

8.51006

HBTU

TOTU Novabiochem®

Sigma-Aldrich

8.51088

TOTU

assay

≥98.0% (HPLC)

assay

≥98% (HPLC)

assay

≥99.0% (HPLC)

assay

≥99.0% (HPLC)

form

powder

form

powder

form

powder

form

powder

mp

195-199 °C (decomposes)

mp

>185 °C

mp

250 °C

mp

142-148 °C

storage temp.

15-25°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

200

General description

See entry for HBTU (851006). TBTU has been employed to generate 1,2,4-oxadiazoles from carboxylic acids [1].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.

Linkage

Replaces: 01-62-0015

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Flam. Sol. 1 - Skin Sens. 1A

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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