MilliporeSigma
All Photos(1)

Documents

8.51010

Sigma-Aldrich

PyBroP

Novabiochem®

Sign Into View Organizational & Contract Pricing

Synonym(s):
PyBroP, Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate
Empirical Formula (Hill Notation):
C12H24BrN3P · F6P
CAS Number:
Molecular Weight:
466.18
MDL number:

Quality Level

product line

Novabiochem®

assay

≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Coupling Reactions

manufacturer/tradename

Novabiochem®

mp

>100 °C

application(s)

peptide synthesis

storage temp.

2-8°C

InChI

1S/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1

InChI key

CYKRMWNZYOIJCH-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
8.512218.510098.51004
PyBroP Novabiochem®

8.51010

PyBroP

PyAOP Novabiochem®

8.51221

PyAOP

PyBOP® Novabiochem®

8.51009

PyBOP®

BOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®

8.51004

BOP

assay

≥98.0% (HPLC)

assay

-

assay

≥99.0% (HPLC)

assay

≥99.0% (HPLC)

form

powder

form

powder

form

powder

form

powder

mp

>100 °C

mp

-

mp

140-155 °C

mp

138-145 °C

storage temp.

2-8°C

storage temp.

15-25°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

200

General description

A superior reagent for rapid and effective coupling of N-methyl amino acids with low enantiomerization and for other critical applications [1,2,3,4,5,6,7,8]. The coupling of N-methyl amino acids is difficult, and usually only gives low to moderate yields of products which are often contaminated with unwanted diastereomers. Many coupling reagents are ineffective or not practical to use: BOP and HOBt are often useless; BOP-Cl, pivaloyl chloride and Dpp-Cl require long reaction times and preactivation at 0°C.For coupling γ-aminoisobutyric acid (Aib), PyBrOP® is most effective when used with dimethylaminopyridine (DMAP) [3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents


Literature references

[1] J. Coste, et al. in ′Peptides, Chemistry, Structure & Biology, Proc. 11th American Peptide Symposium′, J. E. Rivier & G. R. Marshall (Eds), ESCOM, Leiden, 1990, pp. 900.
[2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 669.
[3] J. Coste, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp. 76.
[4] J. Coste, et al. (1991) Tetrahedron Lett., 32, 1967.
[5] P. W. Baures, et al. (1997) J. Peptide Res., 50, 1.
[6] T. Doi, et al. (1999) Synlett, 11, 1751.
[7] A. M. Boldi, et al. (2001) J. Comb. Chem., 3, 367.
[8] S. Gazal, et al. (2001) J. Peptide Res., 58, 527.

Linkage

Replaces: 01-62-0017

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBroP is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service