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For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
8.51012
HCTU
O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®
Synonym(s):
2-(6-Chloro-1-H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate, HCTU
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
25 g | Estimated to ship TODAYfromSAINT LOUIS | $135.00 |
100 g | Estimated to ship TODAYfromSAINT LOUIS | $404.00 $303.00 |
500 g | Estimated to ship onSeptember 16, 2026fromSAINT LOUIS | $551.00 |
1 kg | Estimated to ship onSeptember 16, 2026fromSAINT LOUIS | $813.00 |
5 kg | Check Cart for Availability | $3,270.00 |
About This Item
Quality Segment
product line
Novabiochem®
assay
≥98% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
>185 °C
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
F[P-](F)(F)(F)(F)F.Clc1cc2[n](nnc2cc1)[O+]=C(N(C)C)N(C)C
InChI
1S/C11H15ClN5O.F6P/c1-15(2)11(16(3)4)18-17-10-7-8(12)5-6-9(10)13-14-17;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
InChI key
ZHHGTMQHUWDEJF-UHFFFAOYSA-N
General description
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] O. Marder, et al. (2002) Chimica Oggi, 37.
[2] G. Sabatino, et al. in ′Peptides 2002, Proceedings of the 27th European Peptide Symposium′, E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 272.
[3] M. Gude & S. Barthélémy in ′Peptides 2002, Proceedings of the 27th European Peptide Symposium′, E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 122.
[4] G. Sabatino, et al. in ′Peptide Revolution: Genomics, Proteomics & Therapeutics, , Proc. 18th American Peptide Symposium′, M. Chrev & T. K. Sawyer (Eds), Cardiff, American Peptide Society, 2003, pp. 49.
Application
- High-throughput parallel synthesis optimization of Glucagon-like Peptide 1 receptor agonists: Describes the use of HCTU as a reactive coupling reagent in peptide synthesis, highlighting its effectiveness in the production of GLP-1 agonists. (Ramos-Colón et al., 2018).
- An efficient synthesis of quinoxaline derivatives using HCTU as catalyst in DMF: Outlines a novel method for synthesizing quinoxaline and its derivatives using HCTU, highlighting its catalytic properties in facilitating efficient chemical reactions. (Sasane et al., 2023).
- An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology: Describes the use of HCTU in a methodology to convert carboxylic acids into benzimidazoles, noting its role alongside other carbodiimide agents. (Barasa and Yoganathan, 2018).
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 0.50 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Other Notes
Legal Information
1 of 1
This Item | |||
|---|---|---|---|
| description O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem® | description Novabiochem® | description 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem® | description Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem® |
| assay ≥98% (HPLC) | assay - | assay ≥99.0% (HPLC) | assay - |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| reaction suitability reaction type: Coupling Reactions | reaction suitability reaction type: Coupling Reactions | reaction suitability reaction type: Coupling Reactions | reaction suitability reaction type: Coupling Reactions |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| form powder | form solid | form powder | form solid |
| mp >185 °C | mp 186 °C (decomposes) | mp 250 °C | mp 104-109 °C |
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1A
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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