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8.51061

Sigma-Aldrich

2-Chlorotrityl chloride

Novabiochem®

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Synonym(s):
2-Chlorotrityl chloride
Empirical Formula (Hill Notation):
C19H14Cl2
CAS Number:
Molecular Weight:
313.22
MDL number:
EC Index Number:
255-647-3

Quality Level

product line

Novabiochem®

assay

≥95.0% (HPLC)

form

powder

manufacturer/tradename

Novabiochem®

mp

133.0-137.0 °C

application(s)

peptide synthesis

storage temp.

2-30°C

InChI

1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H

InChI key

JFLSOKIMYBSASW-UHFFFAOYSA-N

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8.51061

2-Chlorotrityl chloride

vibrant-m

26569

2-Chlorotrityl chloride

vibrant-m

8.52371

Fmoc-His(Clt)-OH

vibrant-m

8.08154

Thionyl chloride

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

200

mp

133.0-137.0 °C

mp

130-135 °C

mp

-

mp

-104.5 °C

form

powder

form

solid

form

powder

form

liquid

storage temp.

2-30°C

storage temp.

-

storage temp.

15-25°C

storage temp.

2-30°C

product line

Novabiochem®

product line

-

product line

Novabiochem®

product line

-

General description

Hyperacid-labile ester protecting group [1]. Introduced under extremely mild conditions by reacting together the acid, trityl chloride and DIPEA in DCM. Ideal for the protection of the C-terminal carboxylic acid group of C-terminal protected peptide fragments, monoprotection of diacids and as a general carboxylic acid protecting group in organic synthesis.


Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references

[1] P. Athanassopoulos, et al. (1995) Tetrahedron Lett., 36, 5645.

Linkage

Replaces: 01-63-0045

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Melting range (lower value): ≥ 133 °C
Melting range (upper value): ≤ 137 °C
Assay (HPLC, area%): ≥ 95.0 % (a/a)

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionExclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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