MilliporeSigma
All Photos(1)

Documents

8.51090

Sigma-Aldrich

TFFH

Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem®

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
TFFH, Tetramethylfluoroformamidinium hexafluorophosphate,Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate
Empirical Formula (Hill Notation):
C5H12F7N2P
CAS Number:
Molecular Weight:
264.12
MDL number:

Quality Level

product line

Novabiochem®

form

solid

reaction suitability

reaction type: Coupling Reactions

manufacturer/tradename

Novabiochem®

mp

104-109 °C

application(s)

peptide synthesis

storage temp.

2-8°C

InChI

1S/C5H12FN2/c1-7(2)5(6)8(3)4/h1-4H3/q+1

InChI key

JILUGXGJYPRQPA-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
8.51013096688.51010
TFFH Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem®

Sigma-Aldrich

8.51090

TFFH

HATU Novabiochem®

Sigma-Aldrich

8.51013

HATU

PyBroP Novabiochem®

Sigma-Aldrich

8.51010

PyBroP

form

solid

form

solid

form

crystals

form

powder

mp

104-109 °C

mp

186 °C (decomposes)

mp

218-221 °C (dec.)

mp

>100 °C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

200

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

General description

TFFH is an in situ coupling reagents which smoothly converts protected amino acids to the corresponding acid fluoride in the presence of base [1]. Acid fluorides have proven are highly effective at coupling hindered amino acids such as α,α-disubstituted amino acids [2].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

[1] L. A. Carpino, et al. (1995) J. Am. Chem. Soc., 117, 5401.
[2] S. A. Triolo, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 839.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay 1H-qNMR: ≥ 98.0 %
Ratio Cation/anion in 19F-NMR integration: lot specific result
1:5,7 to 1:6,3
Identity (IR): passes test

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 6

1 of 6

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service