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Sigma-Aldrich

Fmoc-Ile-OH

Novabiochem®

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Synonym(s):
Fmoc-Ile-OH, N-α-Fmoc-L-isoleucine
Empirical Formula (Hill Notation):
C21H23NO4
CAS Number:
Molecular Weight:
353.41
MDL number:
EC Index Number:
276-255-9

Quality Level

product line

Novabiochem®

assay

≥98% (TLC)
≥98.0% (acidimetric)
≥99.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

143-145 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-30°C

InChI

1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/p-1/t13-,19+/m1/s1

InChI key

QXVFEIPAZSXRGM-YJYMSZOUSA-M

General description

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
Standard building block for introduction of isoleucine amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

Application


  • Total synthesis of teixobactin: This article describes the challenges and strategies in synthesizing teixobactin, a promising new antibiotic, highlighting the role of Fmoc-Ile-OH in the synthesis process (Jin et al., 2016).

  • Synthesis and structure–activity relationship studies of teixobactin analogues: Discusses the synthesis of teixobactin analogues using Fmoc-Ile-OH, providing insights into developing more effective antibiotics (Wu et al., 2017).


Linkage

Replaces: 04-12-1024

Analysis Note

Color (visual): white to off white
Appearance of substance (visual): powder
Color index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.7 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Ile-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Ile-Ile-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Leu-OH (GC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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