8.52097

Fmoc-Lys(biotin)-OH

≥95% (TLC), for peptide synthesis, Novabiochem^®

• Synonym(s): Fmoc-Lys(biotin)-OH, N-α-Fmoc-N-ε-biotinyl-L-lysine
• Empirical Formula (Hill Notation): C₃₁H₃₈N₄O₆S
• CAS Number: 146987-10-2
• Molecular Weight: 594.72
• MDL number: MFCD00270741
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Product Name: Fmoc-Lys(biotin)-OH, Novabiochem^®
• Quality Level: 200
• product line: Novabiochem^®
• assay: ≥85.0% (HPLC); ≥95% (TLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: biotin
• storage temp.: 2-30°C
• SMILES string: S1[C@H]([C@H]5NC(=O)N[C@H]5C1)CCCCC(=O)NCCCC[C@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O
• InChI: 1S/C31H38N4O6S/c36-27(15-6-5-14-26-28-25(18-42-26)33-30(39)35-28)32-16-8-7-13-24(29(37)38)34-31(40)41-17-23-21-11-3-1-9-19(21)20-10-2-4-12-22(20)23/h1-4,9-12,23-26,28H,5-8,13-18H2,(H,32,36)(H,34,40)(H,37,38)(H2,33,35,39)/t24-,25-,26-,28-/m0/s1
• InChI key: OFIBQNGDYNGUEZ-OBXRUURASA-N

Description

General description

A modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Biotinylation Reagents for Peptide Synthesis

Application

• Supplemental Information for: Describes the reaction of amino functionalized resin with HCTU-activated Fmoc-Lys(biotin)-OH in DMF to install a biocytin molecule. Fmoc was deprotected by 20% (K Sapkota, JK Lucas, JW Faulkner, MF Lichte, YL Guo, tandf.figshare.com).

Linkage

Replaces: 04-12-1237

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 95 %
Assay (HPLC, area%): ≥ 85.0 % (a/a)
Solubility (0,1 mmole in 1 ml NMP): clearly soluble
Water (K. F.): ≤ 3.0 %
This product can contain up to 10% DMF in order to assure an ideal solubility.

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable