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8.52102

Sigma-Aldrich

Fmoc-Glu(biotinyl-PEG)-OH

Novabiochem®

Synonym(s):
Fmoc-Glu(biotinyl-PEG)-OH, N-α-Fmoc-N-γ-(N-biotinyl-3-(2-(2-(3-aminopropyloxy)-ethoxy)-ethoxy)-propyl)-L-glutamine
Empirical Formula (Hill Notation):
C40H55N5O10S
CAS Number:
Molecular Weight:
797.96
MDL number:

Quality Level

product line

Novabiochem®

Assay

≥95.0% (HPLC)
≥97% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

biotin

storage temp.

2-8°C

InChI

1S/C40H55N5O10S/c46-35(14-6-5-13-34-37-33(26-56-34)43-39(50)45-37)41-17-7-19-52-21-23-54-24-22-53-20-8-18-42-36(47)16-15-32(38(48)49)44-40(51)55-25-31-29-11-3-1-9-27(29)28-10-2-4-12-30(28)31/h1-4,9-12,31-34,37H,5-8,13-26H2,(H,41,46)(H,42,47)(H,44,51)(H,48,49)(H2,43,45,50)/t32-,33-,34-,37-/m0/s1

InChI key

MGOWNVYDCIBVKC-FNHRVDEZSA-N

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This Item
8.521009144368.51038
Fmoc-D-Lys(Biotin)-OH ≥95%

Sigma-Aldrich

914436

Fmoc-D-Lys(Biotin)-OH

product line

Novabiochem®

product line

Novabiochem®

product line

-

product line

Novabiochem®

assay

≥95.0% (HPLC), ≥97% (TLC)

assay

≥90.0% (HPLC), ≥98% (TLC)

assay

≥95%

assay

≥93.0% (HPLC), ≥95% (TLC)

form

powder

form

powder

form

powder

form

oil

functional group

biotin

functional group

biotin

functional group

-

functional group

Fmoc

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

General description

In contrast to Fmoc-Lys(biotin)-OH, this novel biotin-labeled amino acid has excellent solubility in DMF and other solvents used in SPPS [1]. The PEG-spacer restricts hindrance between the peptide and avidin, leading to better biotin binding. Furthermore, the hydrophilic nature of the PEG minimizes non-specific interactions that can arise from the spacer group becoming buried in the hydrophobic pocket of proteins.

For recent applications, please see [2 - 4].

The product number for this product was previously 04-12-1250.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Linkage

Replaces: 04-12-1250

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (0,2 mmol in 1 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Certificate of Analysis

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Certificate of Quality

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