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8.52106

Sigma-Aldrich

Fmoc-Lys(Me,Boc)-OH

Novabiochem®

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Synonym(s):
Fmoc-Lys(Me,Boc)-OH, N-α-Fmoc-N-ε-methyl-N-ε-t.-Boc-L-lysine
Empirical Formula (Hill Notation):
C27H34N2O6
CAS Number:
Molecular Weight:
482.57

Quality Level

product line

Novabiochem®

Assay

≥97.0% (HPLC)
≥98% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

InChI

1S/C27H34N2O6/c1-27(2,3)35-26(33)29(4)16-10-9-15-23(24(30)31)28-25(32)34-17-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h5-8,11-14,22-23H,9-10,15-17H2,1-4H3,(H,28,32)(H,30,31)/t23-/m0/s1

InChI key

JHMSFOFHTAYQLS-QHCPKHFHSA-N

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8.521118.521128.52094
Fmoc-Lys(Me,Boc)-OH Novabiochem®

Sigma-Aldrich

8.52106

Fmoc-Lys(Me,Boc)-OH

Fmoc-Lys(Me₃Cl)-OH Novabiochem®

Sigma-Aldrich

8.52112

Fmoc-Lys(Me₃Cl)-OH

Fmoc-Lys(Mmt)-OH Novabiochem®

Sigma-Aldrich

8.52094

Fmoc-Lys(Mmt)-OH

assay

≥97.0% (HPLC), ≥98% (TLC)

assay

≥95% (TLC), ≥95.0% (HPLC)

assay

≥95% (TLC), ≥95.0% (HPLC)

assay

≥80.0% (acidimetric), ≥95% (TLC), ≥95.0% (HPLC)

form

powder

form

powder

form

powder

form

powder

functional group

amine

functional group

amine

functional group

amine

functional group

amine

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

A novel derivative for the introduction of monomethyl-lysine during Fmoc SPPS [1,2]. Coupling can be carried out using any standard activation method. Removal of the Boc protecting group occurs during the course of the TFA-mediated cleavage reaction. Ref [3] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

[1] A.J. Bannister (2002) Cell, 109, 801.
[2] A.E. McBride & P.A. Silver (2001) Cell, 106, 5.
[3] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Linkage

Replaces: 04-12-1263

Analysis Note

Color (visual): white to light yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): -13.0 - -8.5 °
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Yun Song et al.
Cell reports, 30(8), 2699-2711 (2020-02-27)
The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetylase enzymes, LSD1 and HDAC1, held together by the

Articles

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Protocols

Building Blocks for Introducing Post-translational Modified Amino Acids

We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.

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