8.52107
Fmoc-ADMA(Pbf)-OH
≥98% (TLC), for peptide synthesis, Novabiochem®
Synonym(s):
Fmoc-ADMA(Pbf)-OH, N-α-Fmoc-N,N-ω-dimethyl-N-ωÆ-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
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Product Name
Fmoc-ADMA(Pbf)-OH, Novabiochem®
product line
Novabiochem®
assay
≥96.0% (HPLC)
≥98% (TLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
15-25°C
Quality Level
1 of 4
This Item | 8.52105 | 8.52310 | 8.52106 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥96.0% (HPLC), ≥98% (TLC) | assay ≥95.0% (HPLC) | assay ≥90.0% (HPLC) | assay ≥97.0% (HPLC), ≥98% (TLC) |
| functional group Fmoc | functional group Fmoc | functional group Boc, Fmoc | functional group amine |
| product line Novabiochem® | product line Novabiochem® | product line Novabiochem® | product line Novabiochem® |
| storage temp. 15-25°C | storage temp. 15-25°C | storage temp. -10 to -25°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(157A)): ≥ 98 %
Enantiomeric purity: ≥ 99.0 % (a/a)
Assay (HPLC, area%): ≥ 96.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 2.0 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Application
- Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides: Studies the use of Fmoc-ADMA(Pbf)-OH in modifying peptides to enhance their cellular uptake, relevant for drug delivery systems and therapeutic molecule development (JH Li et al., 2015).
- Advances in Fmoc solid-phase peptide synthesis: Reviews the role of Fmoc-ADMA(Pbf)-OH in advancing peptide synthesis techniques, impacting the field of material science through the development of novel synthetic strategies and applications in biomaterials (R Behrendt, J Offer, 2016).
General description
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.
Other Notes
Legal Information
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Articles
Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.
Protocols
We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.
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