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Sigma-Aldrich

Boc-His(Tos)-OH

Novabiochem®

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Synonym(s):
Boc-His(Tos)-OH, N-α-t.-Boc-N-im-tosyl-L-histidine
Empirical Formula (Hill Notation):
C18H23N3O6S
CAS Number:
Molecular Weight:
409.46
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

product line

Novabiochem®

assay

≥98% (TLC)
≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Boc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

storage temp.

15-25°C

InChI

1S/C18H23N3O6S/c1-12-5-7-14(8-6-12)28(25,26)21-10-13(19-11-21)9-15(16(22)23)20-17(24)27-18(2,3)4/h5-8,10-11,15H,9H2,1-4H3,(H,20,24)(H,22,23)/t15-/m0/s1

InChI key

DCLJSEPKYJSEHW-HNNXBMFYSA-N

General description

Standard building block for introduction of histidine amino-acid residues by Boc SPPS.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

[1] T. Fujii, et al. (1974) Bull. Chem. Soc. Jpn., 47, 3146.
[2] J. M. v. d. Eijk, et al. (1980) J. Org. Chem., 45, 547.

Linkage

Replaces: 04-12-0012

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in dioxan): +10.0 - +13.0 °
Purity (TLC(011B)): ≥ 98 %
Purity (TLC(011C)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (50 mg in ml EtOH): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protocols

Anhydrous HF is the preferred reagent for peptide cleavage from Boc-based resins, versatile and effective for various peptide synthesis.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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