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8.55017

Sigma-Aldrich

2-Chlorotrityl chloride resin (100-200 mesh), 1% DVB

Novabiochem®

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Quality Level

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

storage temp.

2-30°C

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This Item
8.550798.550118.55001
form

beads

form

beads

form

beads

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis, reactivity: alcohol reactive

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-30°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

400

General description

2-Chlorotrityl chloride resin is an extremely versatile, acid-labile resin for the solid phase immobilization of carboxylic acids [1,2,3,4,5,6, 20], alcohols [7,8,9, 20], phenols [10,11,12,13, 20] and amines [14,15,16,17,18,19,20], imidazoles [20] and hydroxylamines [21,22]. Release of these functionalities is generally achieved using 1-50% TFA in DCM containing 5% TIS, although carboxylic acids can also be cleaved from this support with AcOH/TFE/DCM [1,2,3,4,5,6],0.5% TFA in DCM, or HFIP in DCM [23].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis ResinsLiterature references

[1] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3947.
[2] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
[3] K. Barlos, et al. (1991) Angew. Chem. Int. Ed. Engl., 30, 590.
[4] K. Barlos, et al. (1991) Int. J. Peptide Protein Res., 37, 513.
[5] K. Barlos, et al. (1991) Int. J. Peptide Protein Res., 38, 562.
[6] K. Barlos, et al. (1991) Int. J. Peptide Protein Res., 38, 555.
[7] H. Wenschuh, et al. in ′Peptides 1994, Proc. 23rd European Peptide Symposium′, H. Maia (Eds), ESCOM, Leiden, 1995, pp. 287.
[8] H. Wenschuh, et al. (1995) J. Org. Chem., 60, 405.
[9] B. B. Shankar, et al. (1998) Tetrahedron Lett., 39, 2447.
[10] Z. Zhu & B. Mckittrick (1998) Tetrahedron Lett., 39, 7479.
[11] U. Heinelt, et al. (2001) Bioorg. Med. Chem. Lett., 11, 227.
[12] K. J. Elgie, et al. (2000) Tetrahedron Lett., 41, 2753.
[13] S. Batra, et al. (2000) Tetrahedron Lett., 41, 5971.
[14] M. Cardno, et al. (1995) J. Chem. Soc., Chem. Commun., 2163.
[15] I. A. Nash, et al. (1996) Tetrahedron Lett., 37, 2625.
[16] W. J. Hoekstra, et al. (1997) Tetrahedron Lett., 38, 2629.
[17] J. Perumattan, et al. (1998) Mol. Div., 3, 121.
[18] J. J. McNally, et al. (1998) Tetrahedron Lett., 39,967.
[19] M. A. Youngman & S. L. Dax (1997) Tetrahedron Lett., 38, 6347.
[20] A. Bernhardt, et al. (1997) J. Peptide Res., 50, 143.
[21] S. L. Mellor, et al. (1997) Tetrahedron Lett., 38, 3311.
[22] M. M. Meloni & M. Taddei (2001) Org. Lett., 3, 337.
[23] R. Bollhagen, et al. (1994) J. Chem. Soc ., Chem. Commun., 2559.

Linkage

Replaces: 01-64-0114

Analysis Note

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.00 - 1.80 mmol/g
Swelling Volume (in CH₂Cl₂): 2.0 - 5.0 ml/g
Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 4.2 ml/g
The polymer matrix is copoly (styrene-1 % DVB) 100 - 200 mesh.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Protocols

Peptide Resin Loading Protocols

Review methods and resins for attaching amino acids and peptides, including Merrifield, trityl-based, and hydroxymethyl-functionalized resins. Resin-immobilized peptides can be used for various downstream applications.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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