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4-Hydroxymethylbenzoic acid PEGA resin

Quality Level

product line




reaction suitability

reaction type: Fmoc solid-phase peptide synthesis




peptide synthesis

functional group


storage temp.


General description

This support consists of amino PEGA resin derivatized with Sheppard′s base-labile 4-hydroxymethylbenzoic acid linker [1]. For further information, please refer to the product entry for amino PEGA resin(855015). Note: PEGA resins are supplied swollen in ethanol, with 1g dry resin corresponding to approximately 15 mL of swollen resin. As the beads of PEGA resins become very sticky and easily damaged when shrunk or dried, they are best handled in a swollen state. To use, the appropriate amount of swollen resin should be weighed into a reaction vessel and any residual ethanol removed by copious washings with the appropriate solvent or solvent mixture. After peptide assembly, the resin should be washed with DCM and transferred to the cleavage vessel. Excess DCM can be removed under vacuum, and the shrunk resin treated with the TFA cocktail. The characteristics of the swollen resin, its robustness and high permeability enables its use in both batch and continuous flow synthesis apparatus.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] R. C. Sheppard, et al. (1982) Int. J. Peptide Protein Res., 20, 451.


Replaces: 01-64-0113

Analysis Note

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.10 - 0.40 mmol/g
Swelling Volume (in DMF): lot specific result
dry resin %: lot specific result
The resin is sold swollen in ethanol.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Linkers for Fmoc SPPS

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.


Peptide Resin Loading Protocols

Review methods and resins for attaching amino acids and peptides, including Merrifield, trityl-based, and hydroxymethyl-functionalized resins. Resin-immobilized peptides can be used for various downstream applications.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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