869001-M

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

• Synonym(s): Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH
• CAS Number: 9002-68-0
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00131099
• eCl@ss: 42020504
• Biological source: human pituitary glands
• Form: lyophilized solid
• Assay: ≥90%

Properties

• biological source: human pituitary glands
• Quality Segment: 200
• description: Merck USA index - 14, 4223
• sterility: non-sterile
• product line: Calbiochem^®
• assay: ≥90%
• form: lyophilized solid
• specific activity: ≥2000 IU/mg
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• impurities: ≤0.1% hCG, ≤0.5% hLH, hTSH
• pI: 4.1
• solubility: PBS: soluble
• storage temp.: −20°C

Description

General description

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Biochem/physiol Actions

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Costrici, N., et al. 1995. Endocrinology136, 4705.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable