AB1253

Sigma-Aldrich

Anti-Cytochrome P450 Enzyme CYP3A1 Antibody

serum, Chemicon®

eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Chemicon®

application(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Specificity

Reacts with rat cytochrome P450 enzyme CYP3A1 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP3A2.

Immunogen

Synthetic peptide

Application

Research Category
Metabolism
This Anti-Cytochrome P450 Enzyme CYP3A1 Antibody is validated for use in IH, WB for the detection of Cytochrome P450 Enzyme CYP3A1.
Western blot

Immunohistochemistry on formaldehyde treated sections.

Optimal working dilutions must be determined by end user.
Research Sub Category
Enzymes & Biochemistry

Physical form

Rabbit antiserum. Liquid. Contains no preservative.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues.
Debri, K, et al.
Biochemical Pharmacology, 50, 2047-2056 (1995)
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Er-Jia Wang,George Mandakas,Jairam Palamanda,Xinjie Lin,Pramila Kumari,Inhou Chu et al.
Drug and Chemical Toxicology null
F P Guengerich
Annual review of pharmacology and toxicology, 39, 1-17 (1999-05-20)
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues...
Alterations in P-glycoprotein expression in mouse tissues by doxorubicin: implications for pharmacokinetics in multiple dosing regimens.
D L Gustafson, M E Long
Chemico-Biological Interactions null
P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
Daniel L Gustafson, Michael E Long, Erica L Bradshaw, Andrea L Merz, Patrick J Kerzic
Cancer Chemotherapy and Pharmacology null

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