Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues.
Debri, K, et al.
Biochemical Pharmacology, 50, 2047-2056 (1995)
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Er-Jia Wang,George Mandakas,Jairam Palamanda,Xinjie Lin,Pramila Kumari,Inhou Chu et al.
Drug and Chemical Toxicology null
F P Guengerich
Annual review of pharmacology and toxicology, 39, 1-17 (1999-05-20)
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues...
Alterations in P-glycoprotein expression in mouse tissues by doxorubicin: implications for pharmacokinetics in multiple dosing regimens.
D L Gustafson, M E Long
Chemico-Biological Interactions null
P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
Daniel L Gustafson, Michael E Long, Erica L Bradshaw, Andrea L Merz, Patrick J Kerzic
Cancer Chemotherapy and Pharmacology null