Tie-Li Peng et al.
World journal of gastroenterology, 15(14), 1719-1729 (2009-04-11)
To determine the functional significance of aryl hydrocarbon receptor (AhR) in gastric carcinogenesis, and to explore the possible role of AhR in gastric cancer (GC) treatment. RT-PCR, real-time PCR, and Western blotting were performed to detect AhR expression in 39...
Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-I?1.
Koch, et al.
Oncogene, 34, 6092-6104 (2018)
Xiao-Fei Yin et al.
Journal of experimental & clinical cancer research : CR, 31, 46-46 (2012-05-18)
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study was to detect the effects of DIM on gastric cancer cell growth. Gastric cancer cell SGC7901...
De Lin et al.
The Journal of pharmacology and experimental therapeutics, 363(1), 12-19 (2017-09-09)
Ponatinib, a pan-BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML), causes severe side effects including vascular occlusions, pancreatitis, and liver toxicity, although the underlying mechanisms remain unclear. Modifications of critical proteins through reactive metabolites are thought...
Mingli Su et al.
Oncology letters, 14(6), 8100-8105 (2018-01-19)
3'3-Diindolylmethane (DIM) has been proved to exhibit anticancer properties in many solid tumors. In our previous study, we demonstrated that DIM inhibited SGC7901 cell proliferation by inducing apoptosis and delaying cell cycle progression. Herein, we further explored the anti-tumor effect...