AB1528

Anti-Nerve Growth Factor-β Antibody

Name: Anti-Nerve Growth Factor-β Antibody
Brand: MM
Price: 476 USD

serum, Chemicon^®

Synonym(s):

NGFbeta

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250 μL

$476.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Key Documents

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Product Name

Anti-Nerve Growth Factor-β Antibody, serum, Chemicon^®

biological source

sheep

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, chicken, mouse

should not react with

bovine

manufacturer/tradename

Chemicon^®

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_002506.2

UniProt accession no.

P01138

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... NGF(4803)

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Show Differences

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This Item	AB1526	MAB365	MAB5386X
Sigma-Aldrich AB1528 Anti-Nerve Growth Factor-β Antibody	Sigma-Aldrich AB1526 Anti-Nerve Growth Factor-β Antibody	Sigma-Aldrich MAB365 Anti-Nerve Growth Factor Receptor Antibody, extracellular, clone 192-IgG	Sigma-Aldrich MAB5386X Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor^™ 488
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
antibody form serum	antibody form serum	antibody form purified antibody	antibody form purified immunoglobulin
biological source sheep	biological source rabbit	biological source mouse	biological source mouse
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in dry ice
Gene Information human ... NGF(4803)	Gene Information human ... NGF(4803)	Gene Information human ... NGFR(4804)	Gene Information human ... NGFR(4804)
clone polyclonal	clone polyclonal	clone 192-IgG, monoclonal	clone ME20.4, monoclonal

Application

Detect Nerve Growth Factor-β using this Anti-Nerve Growth Factor-β Antibody validated for use in ELISA, WB, IH.

Immunohistochemistry at 1:500-1:5,000 (see suggested protocol).

Immunoblotting at 1:500-1:5,000.

ELISA at 1:500-1:5,000.

Inhibition of biological activity in vitro at 1:10-1:50.
BIOLOGICAL ACTIVITY: Neutralizes NGF, but not other neurotrophins.

Use neat for in vivo animal studies (5-10 μL/g body weight).

Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Neurochemistry & Neurotrophins

Biochem/physiol Actions

Nerve growth factor-beta (NGF). Less than 1% cross-reactivity against recombinant human NT4 and BDNF and approximately 2% for NT3 by ELISA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Mouse nerve growth factor-beta purified from salivary glands.

Physical form

Whole sheep antisera. Lyophilized. Reconstitute with 250 μL of sterile distilled water.

Preparation Note

Maintain at -20°C to -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA.

Daniel Aridgides et al.

PloS one, 8(2), e57450-e57450 (2013-02-26)

Cardiomyocytes express neurotrophin receptor TrkA that promotes survival following nerve growth factor (NGF) ligation. Whether TrkA also resides in cardiac fibroblasts (CFs) and underlies cardioprotection is unknown. To test whether CFs express TrkA that conveys paracrine signals to neighbor cardiomyocytes

Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity.

Scott E Counts et al.

Journal of neurochemistry, 113(3), 649-660 (2010-02-06)

Degeneration of locus coeruleus (LC) noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The physiological consequences of this phenomenon are unclear, but observations correlating LC neuron loss with increased Alzheimer's disease pathology in LC projection sites suggest

Taurine Alleviates Sympathetic Innervation by Inhibiting NLRP3 Inflammasome in Postinfarcted Rats.

Cheng-Che Lee et al.

Journal of cardiovascular pharmacology, 77(6), 745-755 (2021-06-01)

The NLRP3 inflammasome is activated by myocardial infarction and then induces the activation of inflammatory caspase-1 activation and maturation of IL-1β, a regulator of synthesis of the nerve growth factor (NGF). Here, we studied whether taurine, 2-aminoethanesulphonic acid, can attenuate

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