Arrestin-C (UniProt: Q9EQP6; also known as Cone arrestin, cArr, Retinal cone arrestin-3) is encoded by the Arr3 gene (Gene ID: 170735) in murine species. Arrestins are a superfamily of multi-functional proteins that that regulate signaling and trafficking of the majority of G protein-coupled receptors (GPCRs), as well as sub-cellular localization and activity of many other signaling proteins. Arrestin-C is predominantly found in Inner and outer segments, and the inner plexiform regions of the retina. It is expressed in cone photoreceptors and pinealocytes and may contribute to the shut-off mechanisms associated with high acuity color vision. Arrestin-C is an elongated two-domain molecule with overall fold and key inter-domain interactions that hold the free protein in the basal conformation similar to the other subtypes. Several structural elements are reported to contribute to arrestin binding. The C-terminal acidic region serves a regulatory role in controlling arrestin binding selectivity toward the phosphorylated and activated form of a receptor. The basic N-terminal domain directly participates in receptor interaction and serves a regulatory role via intramolecular interaction with the C-terminal acidic region. Also, two centrally localized domains are directly involved in determining receptor binding specificity and selectivity. (Ref.: Gurevich, VV et al. (1995). J. Biol. Chem. 270 (2); 720-731).
This rabbit polyclonal antibody detects Arrestin-C in mouse and rat retina. it targets an epitope with in 12 amino acids from the C-terminal end.
Synthetic Linear Peptide
Anti-Cone Arrestin, Cat. No. AB15282, is a highly specific rabbit polyclonal antibody that targets Arrestin-C and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected Cone Arrestin in rat retina, mouse retina, and mouse cerebral cortex tissue.
Research Sub Category
Sensory & PNS
Evaluated by Western Blotting in mouse retinal tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Cone Arrestin in 10 µg of mouse retinal tissue lysate.
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Concentration: Please refer to lot specific datasheet.
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