AB15518

Sigma-Aldrich

Anti-Neuronal pentraxin 1 Antibody

Chemicon®, from rabbit

Synonym(s):
NPX1
eCl@ss:
32160702

biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse

manufacturer/tradename

Chemicon®

application(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... NPTX1(4884)

General description

Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX1(Neuronal Pentraxin 1) a 432aa protein in mouse and rat, 430aa in human (chr 17q25). It mediates the uptake of degraded synaptic material which could play an important role in synaptic remodeling, expressed in brain.

Specificity

Neuronal pentraxin 1 (NPX1).
The immunogen sequence is 94% conserved in rat, and 82% in human NPX1.

Immunogen

Synthetic peptide near the N-terminus of mouse NPX1

Application

Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Western blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
ELISA: 0.5-1 µg/mL using control peptide.
Optimal working dilutions must be determined by end user.
This Anti-Neuronal pentraxin 1 Antibody is validated for use in ELISA, WB, IH for the detection of Neuronal pentraxin 1.

Physical form

ImmunoAffinity Purified
Liquid in PBS with 0.1% BSA.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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