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MilliporeSigma

AB1555

Sigma-Aldrich

Anti-NMDAR2A Antibody

serum, Chemicon®

Synonym(s):

Anti-EPND, Anti-GluN2A, Anti-LKS, Anti-NMDAR2A, Anti-NR2A

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50 μL
$519.00

$519.00

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

fish, human, rat, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

suitability

not suitable for immunohistochemistry

NCBI accession no.

NM_000833.2

UniProt accession no.

Q12879

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIN2A(2903)

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This Item
SAB2100974AB5403SAB5200888
Anti-NMDAR2A Antibody serum, Chemicon®

Sigma-Aldrich

AB1555

Anti-NMDAR2A Antibody

Anti-GRIN2A antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB2100974

Anti-GRIN2A antibody produced in rabbit

Anti-NMDAR2B Antibody, phosphoTyr 1472 Chemicon®, from rabbit

Sigma-Aldrich

AB5403

Anti-NMDAR2B Antibody, phosphoTyr 1472

Monoclonal Anti-Glun2A/Nr2A antibody produced in mouse clone S327-95, purified immunoglobulin

Sigma-Aldrich

SAB5200888

Monoclonal Anti-Glun2A/Nr2A antibody produced in mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

serum

antibody form

affinity isolated antibody

antibody form

affinity purified immunoglobulin

antibody form

purified immunoglobulin

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

S327-95, monoclonal

UniProt accession no.

Q12879

UniProt accession no.

Q12879

UniProt accession no.

Q13224

UniProt accession no.

Q12879

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

Immunogen

C-Terminal Fusion Protein of the NMDAR2A (30 kDa), aa 1253-1391.

Application

Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
This Anti-NMDAR2A Antibody is validated for use in IP, WB for the detection of NMDAR2A.
Western blotting*: 1:1,000-1:5,000 for ECL. If using labled protein-A for detection: 1:200.

* See suggested protocol

Immunoprecipitation using solubilized hippocampal slices. 3μL will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200μg rat brain.

Not suggested for use in immunohistochemistry.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes.

Physical form

Rabbit antiserum. Liquid, no preservatives.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
NMDAR2A is present in high concentrations in the hippocampus

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effects of repeated prenatal glucocorticoid exposure on long-term potentiation in the juvenile guinea-pig hippocampus.
Setiawan, E; Jackson, MF; MacDonald, JF; Matthews, SG
The Journal of Physiology null
Chung-Che Lu et al.
BMC neuroscience, 22(1), 44-44 (2021-06-27)
The aim of this study was to investigate whether AMN082 exerts its neuroprotective effect by attenuating glutamate receptor-associated neuronal apoptosis and improving functional outcomes after traumatic brain injury (TBI). Anesthetized male Sprague-Dawley rats were divided into the sham-operated, TBI + vehicle, and
Visual experience-independent functional expression of NMDA receptors in the developing rabbit retina.
Chang, YC; Chen, CY; Chiao, CC
Investigative Ophthalmology & Visual Science null
Zhen-Zhen Duan et al.
Scientific reports, 6, 29246-29246 (2016-07-08)
It has been demonstrated that Src could modulate NMDA receptor, and PAR1 could also affect NMDAR signaling. However, whether PAR1 could regulate NMDAR through Src under ICH has not yet been investigated. In this study, we demonstrated the role of
Katherine Leaderbrand et al.
Neurobiology of learning and memory, 113, 35-40 (2013-09-24)
Unpredictable stress is known to profoundly enhance susceptibility to fear and anxiety while reducing the ability to extinguish fear when threat is no longer present. Accordingly, partial aversive reinforcement, via random exposure to footshocks, induces fear that is resistant to
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Related Content

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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