AB1871

Anti-Caspase 1 Antibody

Name: Anti-Caspase 1 Antibody
Brand: MM

Chemicon^®, from rabbit

Synonym(s):

ICE

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Species reactivity:

human, rat, mouse

Citations:

Technique(s):

immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable

Uniprot accession no.:

P29466

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Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat, mouse

manufacturer/tradename

Chemicon^®

technique(s)

immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable

NCBI accession no.

NM_001223.3, NM_033292.2, NM_033293.2, NM_033294.2, NM_033295.2

UniProt accession no.

P29466

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CASP1(834)
mouse ... Casp1(12362)
rat ... Casp1(25166)

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This Item	PRS3459	PRS3463	WH0000834M1
Sigma-Aldrich AB1871 Anti-Caspase 1 Antibody	Sigma-Aldrich PRS3459 Anti-Caspase-1 (ab1) antibody produced in rabbit	Sigma-Aldrich PRS3463 Anti-Caspase-1 (ab2) antibody produced in rabbit	Sigma-Aldrich WH0000834M1 Monoclonal Anti-CASP1 antibody produced in mouse
antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
clone polyclonal	clone polyclonal	clone polyclonal	clone 3D2, monoclonal
shipped in wet ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
UniProt accession no. P29466	UniProt accession no. P29466	UniProt accession no. P29466	UniProt accession no. P29466
technique(s) immunofluorescence: suitable, western blot: suitable, immunoprecipitation (IP): suitable	technique(s) immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

Application

This Anti-Caspase 1 Antibody is validated for use in IF, IP, WB for the detection of Caspase 1.

Western blot: 1-4 μg/mL

Immunoprecipitation: 4-8 μg/mL

Immunofluorescence: 10-20 μg/mL

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

AB1871 recognizes the 45 kDa procaspase-1 as well as the 20 kDa cleaved caspase-1.

General description

Caspase-1 (ICE, interleukin-1b-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1b and IL-18 into active cytokines. Like other caspases, caspase-1 itself is synthesized as a proenzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Physical form

Affinity purified immunoglobulin. Liquid in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

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wgk

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