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AB3796

Sigma-Aldrich

Anti-5′-Lipoxygenase Antibody

Chemicon®, from rabbit

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Synonym(s):
Arachidonate 5-lipoxygenase, 5-LO
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, rat, mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ALOX5(240)

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vibrant-m

AB3796

Anti-5′-Lipoxygenase Antibody

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

saturated ammonium sulfate (SAS) precipitated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

NCBI accession no.

NM_000698.2

NCBI accession no.

NM_000698.2

NCBI accession no.

-

NCBI accession no.

NP_001620

Gene Information

human ... ALOX5(240)

Gene Information

human ... ALOX5(240)

Gene Information

human ... ALOX5(240)

Gene Information

human ... ALOX5AP(241)

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

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General description

5′-Lipoxygenase is a critical enzyme in the formation of leukotrienes from arachidonic acid. Upon activation, the enzyme translocates to either a nuclear or plasma membrane compartment.

Specificity

5′-Lipoxygenase

Immunogen

Purified human 5′-Lipoxygenase

Application

Anti-5′-Lipoxygenase Antibody detects level of 5′-Lipoxygenase & has been published & validated for use in ELISA, IP & WB.
Western blot: 1:1,000. Reacts with a 79 kDa band
Immunoprecipitation: 5 μL/mL lysate
ELISA: 1:1000 – 1:100,000
Optimal working dilutions must be determined by the end user.

Physical form

Format: Purified
Purified immunoglobulin in PBS with 50% Glycerol and 0.02% sodium azide

Analysis Note

Control
POSITIVE CONTROL: placenta, lung, and leukocytes.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2


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Fen Yin et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(6), 1153-1161 (2013-04-06)
To evaluate whether exposure to air pollutants induces oxidative modifications of plasma lipoproteins, resulting in alteration of the protective capacities of high-density lipoproteins (HDLs). We exposed apolipoprotein E-deficient mice to diesel exhaust (DE) at ≈ 250 µg/m(3) for 2 weeks
Daryle J DePianto et al.
JCI insight, 6(8) (2021-03-12)
Compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may precipitate fibrosis. While increased markers of senescence have been reported in idiopathic pulmonary fibrosis (IPF), the origin and identity of these senescent cells remain unclear, and
Anna M Adamusiak et al.
International archives of allergy and immunology, 157(4), 354-362 (2011-11-30)
The pathogenesis of rhinosinusitis in aspirin-exacerbated airway disease is closely linked to the disequilibrium in arachidonic acid metabolism. Although considerable amounts of data concerning impaired eicosanoid production are available, the precise mechanism and pathogenesis of the disease are still unknown.

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