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AB5038

Sigma-Aldrich

Anti-Synuclein α Antibody

serum, Chemicon®

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Synonym(s):
alpha-synuclein, Alpha-synuclein
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SNCA(6622)

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This Item
AB5336PAB5038PAB5334P
vibrant-m

AB5038

Anti-Synuclein α Antibody

vibrant-m

AB5336P

Anti-Synuclein α Antibody

vibrant-m

AB5038P

Anti-Synuclein α Antibody

vibrant-m

AB5334P

Anti-Synuclein α Antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

serum

antibody form

affinity purified immunoglobulin

antibody form

affinity purified immunoglobulin

antibody form

affinity purified immunoglobulin

technique(s)

immunocytochemistry: suitable, western blot: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

technique(s)

immunohistochemistry: suitable (paraffin)

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

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General description

alpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer′s Disease (AD). α-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including α-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).

Specificity

Alpha-synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB5038 with β-synuclein to a minimum. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.
Has not been tested on other species.

Immunogen

Epitope: a.a. 111-131
Human alpha-synuclein residue 111-131 coupled to KLH.

Application

Anti-Synuclein Antibody, α detects level of Synuclein & has been published & validated for use in IC, IH, IH(P) & WB.
Immunohistochemistry:
1:1,000-1:2,000 dilutoin of a previous lot was used on paraffin sections; 1:4,000-1:12,000 dilution of a previous lot was used on frozen sections.

Western blot:
1:1,000-1:2,000. Shows a 14-19kDa band.

Immunocytochemistry:
Previous lot used IC.

Optimal working dilutions must be determined by end user.

Quality

Evaluated by Western Blot on Human Brain lysates.

Western Blot Analysis:
1:1000 dilution of this antibody detected Synuclein on 10 µg of human brain lysates.

Target description

~14-19 kDa

Linkage

Replaces: 04-1053

Physical form

Rabbit polyclonal serum lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue.

Analysis Note

Control
Human brain sections.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis.
Cykowski, MD; Takei, H; Schulz, PE; Appel, SH; Powell, SZ
Acta Neuropathologica Communications null
Dora Games et al.
The American journal of pathology, 182(3), 940-953 (2013-01-15)
Progressive accumulation of α-synuclein (α-syn) in limbic and striatonigral systems is associated with the neurodegenerative processes in dementia with Lewy bodies (DLB) and Parkinson's disease (PD). The murine Thy-1 (mThy1)-α-syn transgenic (tg) model recapitulates aspects of degenerative processes associated with
Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.
Cronin-Furman, EN; Borland, MK; Bergquist, KE; Bennett, JP; Trimmer, PA
Mol. Neurodegener. null
Chiara Maria Giulia De Luca et al.
Translational neurodegeneration, 8, 24-24 (2019-08-14)
Parkinson's disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms. PD is characterized by intraneuronal accumulation of abnormal α-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of either
Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
Sugeno, N; Takeda, A; Hasegawa, T; Kobayashi, M; Kikuchi, A; Mori, F; Wakabayashi, K; Itoyama, Y
The Journal of Biological Chemistry null

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