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Anti-Prox 1 Antibody

serum, Chemicon®

Anti-PROX-1, Anti-A230003G05Rik

biological source


Quality Level

antibody form


antibody product type

primary antibodies



species reactivity

zebrafish, rat, mouse

species reactivity (predicted by homology)





immunocytochemistry: suitable
immunohistochemistry: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

General description

Prox1, the homolog of Drosophila Prospero, is a homeobox-containing transcription factor that binds and functions as a co-receptor of liver receptor homolog 1 (LRH1/NR5A2). It is a specific marker for lymphatic endothelial cells, as well as hepatoblasts and hepatocytes. Human Prox1 shares 97% amino acid sequence identity with mouse and rat Prox1.


Other species have not been tested.
Recognizes Prox1. The antibody is useful for identifying Prox1 expressing cells during the development of many areas of the nervous system including the dorsal spinal cord, ganglionic eminences, thalamus and hippocampus.


Synthetic peptide from the C-terminus of mouse Prox1.


1:2,000-1:10,000 with overnight incubation on 4% paraformaldehyde fixed, frozen tissue sections. For embryos immersion fixation is recommended. For older animals perfusion fixation is recommended. Suggested permeabilization solution is 0.1% Triton X100. Suggested blocking buffer is PBS with 0.1% Triton and 10% serum.

A previous lot of this antibody was used on Immunocytochemistry
Detect Prox 1 using this Anti-Prox 1 Antibody validated for use in IC, IH.

Physical form

Rabbit serum in 50 % glycerol.

Storage and Stability

Stable for 1 year at -20°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Analysis Note

Embryonic brain tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids



Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Quality

Enter Lot Number to search for Certificate of Quality (COQ).

Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells.
C-I Lin,C-N Chen,M-T Huang,S-J Lee,C-H Lin,C-C Chang,H Lee
Cellular and Molecular Life Sciences null
The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish.
Imai, F; Yoshizawa, A; Fujimori-Tonou, N; Kawakami, K; Masai, I
Development null
Nathan C Bird et al.
Methods in molecular biology (Clifton, N.J.), 798, 153-169 (2011-12-02)
During myogenesis, cells gradually transition from mesodermal precursors to myoblasts, myocytes, and then to muscle fibers. The molecular characterization of this process requires the ability to identify each of these cell types and the factors that regulate the transitions between
Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring.
Bick-Sander, Anika, et al.
Proceedings of the National Academy of Sciences of the USA, 103, 3852-3857 (2006)
Byron H Hartman et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 236(10), 2875-2883 (2007-09-08)
Notch mediates the process of lateral inhibition that controls the production of hair cells in the inner ear. Hair cells are known to express Notch ligands Dll1 and Jag2, which signal through Notch1 in adjacent supporting cells. However, recent genetic

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