AB9210

Sigma-Aldrich

Anti-Insulin Degrading Enzyme Antibody

serum, Chemicon®

Synonym(s):
IDE, Insulysin, Insulinase
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

packaging

antibody small pack of 25 μL

manufacturer/tradename

Chemicon®

application(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Related Categories

Specificity

Insulin Degrading Enzyme (IDE). It is expected that the antibody will also react with human and mouse due to immunogen sequence homology.

Immunogen

Synthetic peptide from rat IDE.

Application

Anti-Insulin Degrading Enzyme Antibody is an antibody against Insulin Degrading Enzyme for use in WB.
Research Category
Neuroscience
Western blotting: 1:10,000-1:20,000. The antibody recognizes a protein of ~110 kDa on rat liver tissue lysate.

Optimal working dilutions must be determined by the end user.
Research Sub Category
Neurodegenerative Diseases

Quality

Tested

Physical form

Rabbit serum. Liquid.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Other Notes

Please refer to lot specific datasheet.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice.
Merino, et al.
Metabolism, Clinical and Experimental, 113, 154352-154352 (2020)
Enrique Jurado-Ruiz et al.
Scientific reports, 9(1), 11311-11311 (2019-08-07)
Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet...
Nofar Torika et al.
CNS neuroscience & therapeutics, 24(3), 231-242 (2018-01-25)
Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker...
Geoffrey Canet et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 1150-1168 (2020-01-10)
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis occurs early in Alzheimer's disease (AD), associated with elevated circulating glucocorticoids (GC) and glucocorticoid receptors (GR) signaling impairment. However, the precise role of GR in the pathophysiology of AD remains unclear. Using an acute...
Abhay P Sagare et al.
Nature communications, 4, 2932-2932 (2013-12-18)
Pericytes are cells in the blood-brain barrier that degenerate in Alzheimer's disease (AD), a neurological disorder associated with neurovascular dysfunction, abnormal elevation of amyloid β-peptide (Aβ), tau pathology and neuronal loss. Whether pericyte degeneration can influence AD-like neurodegeneration and contribute...

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