Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice.
Merino, et al.
Metabolism, Clinical and Experimental, 113, 154352-154352 (2020)
Enrique Jurado-Ruiz et al.
Scientific reports, 9(1), 11311-11311 (2019-08-07)
Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet...
Nofar Torika et al.
CNS neuroscience & therapeutics, 24(3), 231-242 (2018-01-25)
Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker...
Geoffrey Canet et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 1150-1168 (2020-01-10)
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis occurs early in Alzheimer's disease (AD), associated with elevated circulating glucocorticoids (GC) and glucocorticoid receptors (GR) signaling impairment. However, the precise role of GR in the pathophysiology of AD remains unclear. Using an acute...
Abhay P Sagare et al.
Nature communications, 4, 2932-2932 (2013-12-18)
Pericytes are cells in the blood-brain barrier that degenerate in Alzheimer's disease (AD), a neurological disorder associated with neurovascular dysfunction, abnormal elevation of amyloid β-peptide (Aβ), tau pathology and neuronal loss. Whether pericyte degeneration can influence AD-like neurodegeneration and contribute...