AB9680

Anti-GABA A Receptor β 1 Antibody

Name: Anti-GABA A Receptor β 1 Antibody
Brand: MM
Price: 416 USD

Chemicon^®, from rabbit

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100 μL

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat, mouse

manufacturer/tradename

Chemicon^®

technique(s)

western blot: suitable

NCBI accession no.

NM_000812.2

UniProt accession no.

P18505

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GABRB1(2560)

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Show Differences

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This Item	SAB4503762	AB9678	AB5561
Sigma-Aldrich AB9680 Anti-GABA A Receptor β 1 Antibody	Sigma-Aldrich SAB4503762 Anti-phospho-GABA-RB (pSer⁴³⁴) antibody produced in rabbit	Sigma-Aldrich AB9678 Anti-GABA A Receptor α 5 Antibody	Sigma-Aldrich AB5561 Anti-GABA A Receptor β2 Antibody, cytoplasmic loop
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity purified immunoglobulin	antibody form affinity purified immunoglobulin
species reactivity human, rat, mouse	species reactivity mouse, rat, human	species reactivity rat, mouse	species reactivity rat, mouse, bovine, human
Gene Information human ... GABRB1(2560)	Gene Information human ... GABRB1(2560)	Gene Information human ... GABRA5(2558)	Gene Information human ... GABRB2(2561)
shipped in dry ice	shipped in wet ice	shipped in dry ice	shipped in dry ice

Immunogen

Fusion protein from the Cytosolic loop of rat the GABAA Receptor beta 1 subunit.

Application

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

This Anti-GABA A Receptor β 1 Antibody is validated for use in WB for the detection of GABA A Receptor β 1.

Western blot: 1:1,000.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

GABAA Receptor beta 1 subunit. The antibody recognizes a protein of ~55 kDa corresponding to GABAA Receptor beta 1 subunit in lysates from rat cerebellum and cortex.

Physical form

Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Preparation Note

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.

Other Notes

Replaces: AB5451

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Differential Dorsolateral Prefrontal Cortex Proteomic Profiles of Suicide Victims with Mood Disorders.

Alejandra Cabello-Arreola et al.

Genes, 11(3) (2020-03-04)

Suicide is a major public health concern; nevertheless, its neurobiology remains unknown. An area of interest in suicide research is the dorsolateral prefrontal cortex (DLPFC). We aimed to identify altered proteins and potential biological pathways in the DLPFC of individuals

mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism.

S Hossein Fatemi et al.

Journal of autism and developmental disorders, 40(6), 743-750 (2010-01-13)

We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and

Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

S H Fatemi et al.

Translational psychiatry, 3, e303-e303 (2013-09-12)

There is abundant evidence that dysfunction of the γ-aminobutyric acid (GABA)ergic signaling system is implicated in the pathology of schizophrenia and mood disorders. Less is known about the alterations in protein expression of GABA receptor subunits in brains of subjects

GABAA and GABAB receptor dysregulation in superior frontal cortex of subjects with schizophrenia and bipolar disorder.

S Hossein Fatemi et al.

Synapse (New York, N.Y.), 71(7) (2017-03-21)

Schizophrenia and bipolar disorder are complex psychiatric disorders that affect millions of people worldwide. Evidence from gene association and postmortem studies has identified abnormalities of the gamma-aminobutyric acid (GABA) signaling system in both disorders. Abnormal GABAergic signaling and transmission could

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