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ABD137

Sigma-Aldrich

Anti-ESRRB Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
Steroid hormone receptor ERR2, ERR beta-2, Estrogen receptor-like 2, Estrogen-related receptor beta, ERR-beta, Nuclear receptor subfamily 3 group B member 2
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ESRRB(2103)

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ABD101SAB4500814SAB1410347
vibrant-m

ABD137

Anti-ESRRB Antibody

vibrant-m

ABD101

Anti-ESRRB Antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Gene Information

human ... ESRRB(2103)

Gene Information

human ... ESRRB(2103)

Gene Information

human ... ESR2(2100)

Gene Information

human ... ESRRA(2101)

species reactivity

human

species reactivity

mouse

species reactivity

human, rat, mouse

species reactivity

human

UniProt accession no.

O95718

UniProt accession no.

O95718

UniProt accession no.

Q92731

UniProt accession no.

P11474

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General description

Steroid hormone receptor ERR2, also known as ERR beta-2 or Estrogen receptor-like 2 or Estrogen-related receptor beta (ERR-beta), and encoded by the gene name ESRRB or ERRB2 or ESRL2, was initially identified in mouse embryonic carcinoma stem cells and was found to be expressed exclusively in trophoblast progenitor cells between days 6.5 and 7.5 post coitum. Recent studies have shown that ESRRB is part of an POU5F1/Oct4-centered protein interaction network in embryonic stem (ES) cells. It is thought to interact with other ES transcription factors such as NANOG within this network, activating POU5F1 transcription and thereby sustaining self-renewal and pluripotency in ES cells. Mutations in ESRRB have been associated with autosomal recessive deafness which is a form of non-syndromic deafness characterized by non-progressive, prelingual hearing loss.

Specificity

Uniprot describes 2 isoforms produced by alternative splicing at ~56 kDa and 1 isoform at ~48 kDa.

Immunogen

Epitope: N-terminus
KLH-conjugated synthetic peptide corresponding to the N-terminus of human ESRRB.

Application

Anti-ESRRB Antibody detects level of ESRRB & has been published & validated for use in ESRRB.
Research Category
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation

Quality

Evaluated by Western Blotting in Human heart tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected ESRRB in Human heart tissue lysate with and without blocking peptide.

Target description

~59 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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