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ABN1441

Sigma-Aldrich

Anti-ABCA4

from rabbit, purified by affinity chromatography

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Synonym(s):
Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein
eCl@ss:
32160702

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

ambient

target post-translational modification

unmodified

Gene Information

human ... ABCA4(24)

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Anti-ABCA4 from rabbit, purified by affinity chromatography

ABN1441

Anti-ABCA4

Anti-ABCA4 Antibody, clone 3F4 clone 3F4, from mouse

MABN2439M

Anti-ABCA4 Antibody, clone 3F4

Anti-ABCA4 Antibody, clone TMR1 clone TMR1, from mouse

MABN1775

Anti-ABCA4 Antibody, clone TMR1

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

affinity isolated antibody

species reactivity

human

species reactivity

bovine, human, mouse

species reactivity

human, mouse

species reactivity

human

clone

polyclonal

clone

3F4, monoclonal

clone

TMR1, monoclonal

clone

polyclonal

shipped in

ambient

shipped in

-

shipped in

wet ice

shipped in

wet ice

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General description

Retinal-specific ATP-binding cassette transporter (UniProt: P78363; also known as ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein) is encoded by the ABCA4 (also known as ABCR) gene (Gene ID: 24) in human. ABC transporter A4 is a multi-pass membrane protein of the superfamily of ATP-binding cassette (ABC) transporters that is localized to the disk margins of vertebrate photoreceptor outer segments. It is implicated in the clearance of all-trans retinal derivatives from rod and cone photoreceptor cells following photoexcitation as part of the visual cycle. ABC transporter A4 is composed of two symmetrically organized halves, each comprising six membrane-spanning helices, a large glycosylated exocytoplasmic domain located inside the disk, and a cytoplasmic domain with an ATP-binding cassette. Mutations in ABCA4 gene are known to cause Stargardt macular degeneration, which is an autosomal recessive form of juvenile macular degeneration associated with a severe loss in vision. Mutations in ABCA4 gene are also known to cause retinitis pigmentosa, which is characterized by retinal pigment deposits and loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. (Ref.: Tsybovsky, Y., et al. (2010). Adv. Exp. Med. Biol. 703, 105-125).

Specificity

This rabbit polyclonall antibody detects Retinal-specific ATP-binding cassette transporter (ABCA4) in Human retina. It targets an epitope within 112 amino acids from the cytoplasmic domain.

Immunogen

GST-tagged reombinant fragment corresponding to 112 amino acids from the internal region of human Retinal-specific ATP-binding cassette transporter (ABCA4).

Application

Anti-ABCA4, Cat. No. ABN1441, is a highly specific rabbit polyclonal antibody that targets Retinal-specific ATP-binding cassette transporter (ABCA4) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected ABCA4 in human retina tissue.
Research Category
Neuroscience

Quality

Evaluated by Western Blotting in human retina tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected ABCA4 in 10 µg of human retina tissue lysate.

Target description

~256 kDa observed; 255.94 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Physical form

Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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