MilliporeSigma
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ABN16

Sigma-Aldrich

Anti-GPR56 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):
G protein-coupled receptor 56, 7-transmembrane protein with no EGF-like N-terminal domains-1, Protein TM7XN1, G-protein coupled receptor 56
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse

technique(s)

immunohistochemistry: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

wet ice

Gene Information

human ... GPR56(9289)

General description

G-protein coupled receptor 56 (GPR56) is a novel, multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and containing a characteristic, extracellular GPS domain. Although newly discovered, studies have suggested roles for the protein in the adhesion between developing neurons, regulating the integrity of pial basement membranes, regulating corticogenesis, and may also be involved in cancer cell metastasis and adhesion. Expression has been observed in a wide variety of peripheral tissues, but the most significant levels have been reported in brain, heart, and thyroid gland. Defects in GPR56 expression cause bilateral frontoparietal polymicrogyria (BFPP), a malformation of the brain in humans that is characterized by ataxia, seizures, disfigurement of the cerebral cortex, and mental retardation.

Specificity

This antibody recognizes GPR56 at the N-terminus.

Immunogen

Epitope: N-terminus
Linear peptide corresponding to the N-terminus sequence of mouse GPR56.

Application

Detect GPR56 using this Anti-GPR56 Antibody validated for use in IH.
Immunohistochemistry Analysis: 1:200 dilution of this antibody from a previous lot detected GPR56 in anal carcinoma and testicular teratoma tissue.
Research Category
Neuroscience

Neuroscience
Research Sub Category
Neurodegenerative Diseases

Neurotransmitters & Receptors

Quality

Evaluated by Immunohistochemistry in inflammatory skin biopsy tissue.

Immunohistochemistry Analysis: 1:200 dilution of this antibody detected GPR56 in inflammatory skin biopsy tissue.

Target description

77 kDa calculated

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.05% sodium azide with 50% Glycerol.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Analysis Note

Control
Inflammatory skin biopsy tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Quality

Enter Lot Number to search for Certificate of Quality (COQ).

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