ABN60

Anti-Tryptophan hydroxylase 2 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): tryptophan hydroxylase 2, Tryptophan 5-monooxygenase 2, Neuronal tryptophan hydroxylase, tryptophan 5-hydroxylase 2
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: immunohistochemistry; western blot
• Species reactivity: human, rat
• Citations: 25
• Technique(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• Uniprot accession no.: Q8IWU9

Properties

• Product Name: Anti-Tryptophan hydroxylase 2 Antibody, from rabbit, purified by affinity chromatography
• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human, rat
• species reactivity (predicted by homology): mouse (immunogen homology)
• technique(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI accession no.: NP_775567
• UniProt accession no.: Q8IWU9
• shipped in: wet ice
• target post-translational modification: unmodified
• Quality Level: 100
• Gene Information: human ... TPH2(121278)

Description

Analysis Note

Control
Rat brain tissue lysate

Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Tryptophan hydroxylase 2 on 10 µg of rat brain tissue lysate.

Application

Anti-Tryptophan hydroxylase 2 Antibody detects level of Tryptophan hydroxylase 2 & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Tryptophan hydroxylase 2 in rat cerebral cortex tissue.

Research Category
Neuroscience

Research Sub Category
Signaling Neuroscience

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Tryptophan hydroxylase 2 (TPH2) is preferentially expressed in the brain and is thought to play an important role in serotonin synthesis. Recent research has actually associated high levels of TPH2 with risk of suicide. Misfolding of TPH2 may be the cause of a loss of serotonin neuronal function in Parkinson’s disease. Detection and screening of particular mutations in TPH2 has been cited as an approach toward predicting patient sensitivity to potential antidepressant therapies and even the possibility of diagnosis of behavioral disorders.

~56 kDa observed

Immunogen

KLH-conjugated linear peptide corresponding to human Tryptophan hydroxylase 2.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable