MilliporeSigma
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AG270

Sigma-Aldrich

Neurocan, chicken

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eCl@ss:
32160702
NACRES:
NA.41

biological source

chicken

Quality Level

form

liquid

manufacturer/tradename

Chemicon®

concentration

100 μg/mL

technique(s)

ELISA: suitable
cell culture | mammalian: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

chicken ... NCAN(395493)

General description

Neurocan, chicken.
Product Source: Chicken Brain.

Application

Inhibition of cell-cell adhesion, cell-ECM adhesion or cell migration at:

0.1 to 30 micrograms / mL.

ELISA Assay: 0.05 to 5 micrograms / mL

Optimal working concentrations must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

Physical form

Purified Neurocan in PBS. Contains no preservative.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Analysis Note

A mix of Chondroitin Sulfate Proteoglycans from chick brain (Chemicon CC117) was purified by the unique density and size of this class of molecules. Neurocan is purified from this mix using an immobilized monoclonal antibody. The resulting neurocan is pure and has chondroitin sulfate attached. Removing the chondroitin sulfate with chondroitinase, results in core proteins are primarily the full-length 250 kD form and a little of smaller neurocan fragments.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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H Ernst et al.
Journal of cell science, 108 ( Pt 12), 3807-3816 (1995-12-01)
Chondroitin sulfate proteoglycans inhibit the adhesion of cells to extracellular matrix proteins that otherwise permit adhesion. Although proteoglycans are widely assumed to act by masking the other protein in a mixed substrate, recent studies suggest that proteoglycans inhibit adhesion through
E U Sumer et al.
Osteoarthritis and cartilage, 15(2), 212-221 (2006-09-26)
Aggrecan is the major proteoglycan in articular cartilage and is known to be degraded by various proteases, including matrix metalloproteinases (MMPs). The present study was undertaken to develop immunoassays detecting aggrecan and its fragments generated by MMP and non-MMP-mediated proteolysis.
The interaction of the retina cell surface N-acetylgalactosaminylphosphotransferase with an endogenous proteoglycan ligand results in inhibition of cadherin-mediated adhesion.
Balsamo, J, et al.
The Journal of cell biology, 129, 1391-1401 (1995)

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